Duodenal ulcers which do not heal rapidly.

Duodenal ulcers that will not heal.

Treatment of Gastric and Duodenal Ulcers

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Genital ulcers: do not forget Behçet disease.

1 of 2 DESCRIPTION A 22-year-old, previously healthy, woman was referred to our department for genital ulcers present for more than 1 year, with no resolution to the various treatments prescribed. At physical examination, the patient presented a painful ulcer with a central necrotic base and clean margin about 10 mm in diameter on the right labia majora ( fi gure 1 ) and a similar lesion at the...

Masters of Immunology Tumors: Wounds That Do Not Heal—Redux

Similarities between tumors and the inflammatory response associated with wound healing have been recognized for more than 150 years and continue to intrigue. Some years ago, based on our then recent discovery of vascular permeability factor (VPF)/ VEGF, I suggested that tumors behaved as wounds that do not heal. More particularly, I proposed that tumors co-opted the wound-healing response to i...

Activated protein C to heal pressure ulcers.

Pressure ulcers present a major clinical challenge, are physically debilitating and place the patient at risk of serious comorbidities such as septic shock. Recombinant human activated protein C (APC) is an anticoagulant with anti-inflammatory, cytoprotective and angiogenic effects that promote rapid wound healing. Topical negative pressure wound therapy (TNP) has become widely used as a treatm...